Self-reported Medication Adherence and CKD Progression

Self-reported Medication Adherence and CKD Progression

Blog Article

Introduction: In the general population, medication nonadherence contributes to poorer outcomes.However, little is known about medication adherence among adults with chronic kidney disease (CKD).We evaluated the association of self-reported medication adherence with CKD progression and all-cause death in patients with CKD.

Methods: In this prospective observational study of 3305 adults with mild-to-moderate CKD enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study, the baseline self-reported medication adherence was assessed by responses to 3 questions and categorized as high, medium, and low.CKD progression (50% decline in eGFR or incident end-stage renal disease) NFL Packs and all-cause death were measured using multivariable Cox proportional hazards.Results: Of the patients, 68% were categorized as high adherence, 17% medium adherence, and 15% low adherence.

Over a median follow-up of 6 years, there were 969 CKD progression events and 675 deaths.Compared with the high-adherence group, the low-adherence group experienced increased risk for CKD progression (hazard ratio = 1.27, 95% confidence interval = 1.

05, 1.54) after adjustment for sociodemographic and clinical factors, cardiovascular medications, number of medication types, and depressive symptoms.A similar association existed between low adherence and all-cause death, but did not reach standard statistical significance (hazard ratio = 1.

14 95% confidence interval = 0.88, 1.47).

Conclusion: Baseline self-reported low medication MAG W D adherence was associated with an increased risk for CKD progression.Future work is needed to better understand the mechanisms underlying this association and to develop interventions to improve adherence.Keywords: CKD, death, medication adherence, progression.